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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CCL22</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_CCL22" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">CCL22
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<td>Andere Namen
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<td colspan="2">
<ul><li>Chemokine (C-C Motif) Ligand 22</li>
<li>SCYA22</li>
<li>Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22</li>
<li>Stimulated T-Cell Chemotactic Protein 1</li>
<li>Macrophage-Derived Chemokine</li>
<li>CC Chemokine STCP-1</li>
<li>MDC(1-69)</li>
<li>A-152E5.1</li>
<li>DC/B-CK</li>
<li>ABCD-1</li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
</th></tr>
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">93 Aminosäuren, 10625 Da
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL22">CCL22</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/602957">602957</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O00626">O00626</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=O00626">Hovergen</a>
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
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<td style="background:#C3FDB8; color:#202122;">
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6367&rn=1">6367</a></span>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20299&rn=1">20299</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O00626">O00626</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O88430">O88430</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6367">6367</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=20299">20299</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>CCL22</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic"><i>CC-chemokine ligand 22</i></span>) ist ein <a href="Zytokin" title="Zytokin">Zytokin</a> aus der Familie der CC-<a href="Chemokin" title="Chemokin">Chemokine</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>CCL22 ist an <a href="Entz%C3%BCndung" title="Entzündung">Entzündungsprozessen</a> beteiligt. Es bindet an <a href="CCR4" title="CCR4">CCR4</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> CCL22 wird von <a href="Makrophage" title="Makrophage">Makrophagen</a> und <a href="Dendritische_Zelle" title="Dendritische Zelle">dendritischen Zellen</a> gebildet und bindet dendritische Zellen und <a href="TH2" class="mw-redirect" title="TH2">TH2</a>-Zellen.<sup id="cite_ref-PMID_12433129_2-0" class="reference"><a href="#cite_note-PMID_12433129-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Es wird durch die Zytokine <a href="Interleukin-4" class="mw-redirect" title="Interleukin-4">Interleukin-4</a> und <a href="Interleukin-5" class="mw-redirect" title="Interleukin-5">Interleukin-5</a> induziert und durch <a href="Interferon-gamma" class="mw-redirect" title="Interferon-gamma">Interferon-gamma</a> herabreguliert.<sup id="cite_ref-PMID_12433129_2-1" class="reference"><a href="#cite_note-PMID_12433129-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> CCL22 ist an einer TH2-<a href="%C3%9Cberempfindlichkeitsreaktion" class="mw-redirect" title="Überempfindlichkeitsreaktion">Hypersensitivität</a> der Atemwege und an der atopischen Dermatitis beteiligt.<sup id="cite_ref-PMID_12433129_2-2" class="reference"><a href="#cite_note-PMID_12433129-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">M. Vulcano, C. Albanesi, A. Stoppacciaro, R. Bagnati, G. D’Amico, S. Struyf, P. Transidico, R. Bonecchi, A. Del Prete, P. Allavena, L. P. Ruco, C. Chiabrando, G. Girolomoni, A. Mantovani, S. Sozzani: <i>Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.</i> In: <i>European Journal of Immunology.</i> Band 31, Nummer 3, März 2001, S. 812–822, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/1521-4141%28200103%2931%3A3%3C812%3A%3AAID-IMMU812%3E3.0.CO%3B2-L">10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11241286?dopt=Abstract">PMID 11241286</a>.</span>
</li>
<li id="cite_note-PMID_12433129-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-PMID_12433129_2-0">a</a></sup> <sup><a href="#cite_ref-PMID_12433129_2-1">b</a></sup> <sup><a href="#cite_ref-PMID_12433129_2-2">c</a></sup></span> <span class="reference-text">U. Yamashita, E. Kuroda: <i>Regulation of macrophage-derived chemokine (MDC, CCL22) production.</i> In: <i>Critical reviews in immunology.</i> Band 22, Nummer 2, 2002, S. 105–114, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12433129?dopt=Abstract">PMID 12433129</a>.</span>
</li>
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